Memorial address to Dr. Isabelle Rapin.

Dr. Isabelle Rapin passed away on May 25, 2017. She was a highly skilled clinical pediatric neurologist, a great teacher who mentored and trained many pediatric neurologists and professionals in her field, and a respectable clinical researcher. She defined herself as an academic clinical investigator in her ‘‘Memoir” published in Brain & Development (Brain Dev 33:450–453, 2011 and 33:537–540, 2011). She also wrote her bibliography in the Journal of Child Neurology (J Child Neurol 16:352– 355, 2001). Her academic and personal backgrounds were described with her own words in detail in these ‘‘essays.” While her brilliant brain was probably inherited genetically, it was polished up by her desire to know the truth about the pediatric brain, to read various books on topics ranging from science to literature, to learn from her patients, and to serve her patients for their happiness. Dr. Rapin published a tremendous amount of highquality academic papers and books about childhood neurological diseases from her unique observation and deep foresight. In particular, she focused on the inherited metabolic diseases formerly classified as ‘‘degenerative diseases” and the development and dysfunction of language in children. Her interests in matters related to language acquisition in childhood, by necessity, pervaded to the autistic disorder, thus resulting in a book published in 2006, entitled ‘‘Autism: a neurological disorder of early brain development.” She focused her attention on every aspect of autism. Autistic regression especially in language, which may be the same condition as ‘‘disintegrative disorder,” was one of her targets to challenge. She had insight that the principal symptom of the language disorder in Landau-Kleffner syndrome was ‘‘verbal agnosia.” Dr. Rapin graduated from Lausanne Medical School in Switzerland. With a Swiss father and an American mother, she grew up in intellectual and French–English bilingual circumstances. She spent 6 weeks at the Department of Neurology at Salpetriere and another 6 weeks at Enfants Malades in Paris as a medical stu-